| 7:00 p.m. CT | Alcester-Hudson | Colman-Egan | |||||
| 7:00 p.m. CT | Avon | Gayville-Volin | |||||
| 6:00 p.m. MT | Bison | Faith | |||||
| 7:00 PM CT | Bon Homme | Kimball/White Lake | |||||
| 7:00 PM CT | Britton-Hecla | Deuel | |||||
| 7:00 p.m. CT | Burke | Tripp-Delmont/Armour/AC/DC | |||||
| 7:00 p.m. CT | Centerville | Estelline/Hendricks | |||||
| 7:00 PM CT | Clark/Willow Lake | Hamlin | |||||
| 7:00 PM CT | Corsica-Stickney | Colome | |||||
| 7:00 PM CT | De Smet | Castlewood | |||||
| 7:00 PM CT | Dell Rapids | Tri-Valley | |||||
| 7:00 p.m. CT | Deubrook Area | Elkton-Lake Benton | |||||
| 6:00 p.m. MT | Douglas | Brookings | |||||
| 6:00 p.m. MT | Dupree | Harding County | |||||
| 7:00 PM CT | Elk Point-Jefferson | Wagner | |||||
| 7:00 PM CT | Flandreau | Bridgewater-Emery/Ethan | |||||
| 7:00 PM CT | Gregory | Parkston | |||||
| 7:00 p.m. CT | Groton Area | Redfield | |||||
| 7:00 PM CT | Hanson | Baltic | |||||
| 7:00 PM CT | Harrisburg | Sioux Falls Roosevelt | |||||
| 6:30 p.m. MT | Hill City | Newell | |||||
| 6:00 PM MT | Hot Springs | Bennett County | |||||
| 7:00 p.m. CT | Howard | Irene-Wakonda | |||||
| 7:00 p.m. MT | Lemmon/McIntosh | Timber Lake | |||||
| 7:00 PM CT | Lennox | Canton | |||||
| 7:00 PM CT | Lyman | Jones County/White River | |||||
| 7:00 PM CT | Madison | Tea Area | |||||
| 7:00 PM CT | McCook Central/Montrose | Garretson | |||||
| 7:00 p.m. CT | Mobridge-Pollock | Sisseton | |||||
| 7:00 PM CT | Mt. Vernon/Plankinton | Winner | |||||
| 7:00 p.m. MT | New Underwood | Kadoka Area | |||||
| 7:00 p.m. CT | North Border | Ipswich/Edmunds Central | |||||
| 7:00 p.m. CT | Oldham-Ramona/Rutland | Arlington/Lake Preston | |||||
| 7:00 PM CT | Parker | Viborg-Hurley | |||||
| 7:00 PM CT | Pierre T.F. Riggs | Spearfish | |||||
| 7:00 PM CT | Platte-Geddes | Wolsey-Wessington | |||||
| 6:00 PM MT | Rapid City Central | O’Gorman | |||||
| 7:00 p.m. MT | Rapid City Christian | Edgemont | |||||
| 7:00 PM CT | Sioux Falls Christian | Vermillion | |||||
| 5:00 p.m. CT | Sioux Falls Washington | Rapid City Stevens | |||||
| 6:00 PM MT | Sturgis Brown | Huron | |||||
| 7:00 PM CT | Sully Buttes | Hitchcock-Tulare | |||||
| 7:00 PM MT | Wall | Philip | |||||
| 7:00 PM CT | Warner | Northwestern | |||||
| 7:00 PM CT | Waverly-South Shore | Dakota Hills | |||||
| 7:00 PM CT | Webster Area | Milbank | |||||
| 7:00 PM CT | West Central | Dakota Valley | |||||
| 7:00 p.m. CT | Woon./Wess. Springs/Sanborn Central | Miller/Highmore-Harrold | |||||
| 7:00 PM CT | Yankton | Mitchell | |||||
| Sep 26 | 7:00 PM CT | Great Plains Lutheran | Florence/Henry | ||||
| Sep 26 | 6:00 p.m. CT | Sioux Falls Lincoln | Aberdeen Central | ||||